4th Hokage (Yondaime)
The 4th is actually quite like the itachi that we've been described to so far. He is nice on the outside and all but he is actually very uneasy with his position. On one hand, he has a duty to protect the village; on the other hand he feels the village puts a limit on his growing power. so during the raid of Kyubi( nine tail), 4th sealed the fox in the belly of his son naruto and left the village with his wife and founded Akatsuki. when the battle is over, and the 3rd saw the seal (and 4th instructions?), he mistakenly thought 4th used the forbiden technique and died. the whole village believing in the 3rd, and the legend of 4th lived on.

4th's wife
Naruto's mother, 3rd daughter. loving mother and loyal wife. she left her new born son with tears. later, she became a member of Akatsuki group. rank #8.

Itachi
After the 4th left Konoha, he sends invatation for the 3 most potential shinobi in the vilage. Orochimaru, Jiraya and Itachi. Orochimaru accepted immediately, but Jiraya and Itachi refused. 4th doesn't want to go against the will of his old sensei, but he did not give up on young Itachi. (i think there is a time lag between inviting oro and Itachi) 4th threatens to kill the Uchiha clan, Itachi still wont give in. thus 4th sends #2 ranked Akatsuki "white tiger" to murder most of Uchiha clan. Seeing that he is no match to Akatsuki, Itachi agreed to join if "white tiger" would spare Sasuke. Itachi want his brother to became stronger than him, thus lied about the family's death, hoping to let Sasuke's anger to become his strength. Itachi then joined Atatsuki as #3, Orochimaru as #5.

Orochimaru
Orochimaru's leaving Konoha was strongly objected by Jiraya. Jiraya ,always believed he could save Orochimaru, finally tipped the 3rd about Oro's secrect place, hoping his sensai would finally talk him out of it. (I dont think this is the same event that was shown in the anime, Oro left village long before Kyubi's attack) In Akatsuki, Orochimaru never trusted Itachi's loyalty with the group, and always was bitter about his being #5. He told 4th about Itachi's real loyalty does not lie with Akatsuki. 4th told Orochimaru if you have the power of Sharingan, then i'll believe you. Orochimaru then challenges Itachi but lost to Sharingan. He then left the group.

Sasuke
Sasuke did not really turn evil. He only wanted to pocess more power. Sasuke's sharingan became more powerfull and eventually killed orochimaru with the help of Kabuto. In the end Sasuke killed Itachi and finally found out the truth, and was send again into despair.

Kakashi
Kakashi died in the battle with "white tiger" while protecting Gai-sensei.(Lee's sensei)

Naruto
Naruto's final battle is with his father, the legendary "Yellow Flash", the 4th Hokage. Naruto defeated 4th with the help from his mother (died while protecting Naruto, but wounded 4th).In the end, naruto became Hokage as he wished.

Others:
Sakura became Tsunade's student. Gaara became Kazekage of sand village. Hinata and Naruto got together, so is Shikamaru and Temari. ( some are told by manga already)